Toxicogenomics Challenges and Applications
Heart and blood vessel disease also called cardiovascular disease includes numerous problems, many of which are related to a process called atherosclerosis. Atherosclerosis is a condition that develops when a substance called plaque builds up in the walls of the arteries. This buildup narrows the arteries, making it harder for blood to flow through. If a blood clot forms, it can stop the blood flow. This can cause a heart attack or stroke.
There are four main types of cardiovascular diseases. They are:
- Coronary heart disease
- Stroke
- Peripheral arterial disease
- Aortic disease
- Toxicogenomics in regulatory application
- Toxicogenomics Roles
- Environmental and Comparative Toxicogenomics
- Toxicogenomics as a predictive tool
- Challenges of conventional toxicology approaches
- Bioinformatics and interpretive challenges in toxicogenomics
- Signature/biomarker qualification
- Screening tools to predict toxicity & targets
- SAR/QSAR models
- Hypothesis generation to aid in the determination of MOA(s)
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