Toxicogenomics Challenges and Applications

Heart and blood vessel disease also called cardiovascular disease includes numerous problems, many of which are related to a process called atherosclerosis. Atherosclerosis is a condition that develops when a substance called plaque builds up in the walls of the arteries. This buildup narrows the arteries, making it harder for blood to flow through. If a blood clot forms, it can stop the blood flow. This can cause a heart attack or stroke.

There are four main types of cardiovascular diseases. They are:

  • Coronary heart disease
  • Stroke
  • Peripheral arterial disease
  • Aortic disease

  • Toxicogenomics in regulatory application
  • Toxicogenomics Roles
  • Environmental and Comparative Toxicogenomics
  • Toxicogenomics as a predictive tool
  • Challenges of conventional toxicology approaches
  • Bioinformatics and interpretive challenges in toxicogenomics
  • Signature/biomarker qualification
  • Screening tools to predict toxicity & targets
  • SAR/QSAR models
  • Hypothesis generation to aid in the determination of MOA(s)

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