Eugene Jamot Ndebia
Walter Sisulu University, South Africa
Title: Preliminary in vivo screening of experimentally induced gastric ulcer of Ledebouria ovatifolia
Biography
Biography: Eugene Jamot Ndebia
Abstract
Ledebouria ovatifolia is a wild plant widely used for medicinal purposes including diarrhoea, stomach ache and gastric ulcer in Africa rural settings. This preliminary screening aimed to evaluate the healing effect of L. ovatifolia on experimental induced gastric ulcer in vivo. Indomethacin (50 mg/kg, p. o.), ethanol (2 ml/rat, p. o.) and stress were used to induce gastric ulcer. The anti-ulceration lesion index was calculated, also the macroscopic and histopathologic assessment were made. The results showed that oral administration of L. ovatifolia significantly decreases gastric ulcer as compared to control group. Macroscopic and histopathologic evaluation of ulcerated stomachs of L. ovatifolia treated groups showed a reduced area of gastric lesion, with moderate disruption of the gastric epithelium as well as the mucosa stromal cell. This finding suggested that L. ovatifolia can be used for its anti-ulcerogenic properties, which may support evidence for its traditional utilization.